Clément Milet
Director of Laboratory & Quality - CTIBiotech
Clément MILET joined CTIBIOTECH in 2017 to lead the 3D bioprinting program, advancing the organization’s capabilities in 3D cell and tissue culture. He has extensive experience in developing technologies for research, diagnostics, and cancer screening.
His previous work at the Institute of Advanced Biosciences (Grenoble, France) on cellular chips for RNA screening, and at the Lyon Cancer Research Center (CRCL, France), provided him with a deep understanding of the need for three-dimensional cancer models. At CTIBIOTECH, he applied this experience to patient-derived primary cancerous and skin tissues, creating 3D-bioprinted microtumor and skin models.
Since 2020, Clément Milet has been the Laboratory and Quality Director at CTIBiotech, overseeing various research programs and expanding production capabilities, particularly through 3D bioprinting.
Participation
3D bioprinting and neuro-cosmetics: assess your products’ emotional impact on a smart, connected artificial skin
Epidermal keratinocytes are not only the terminal endpoints of neuronal receptors for heat, pain, and touch, but they also possess a strong intrinsic bioelectric capacity and regulation through abundant ion channels, transporters, and pumps. Even more significant is the polarization of keratinocytes during wound healing and aging-related changes.
Dry skin has an electrical resistance exceeding 100,000 ohms (Ω), which decreases when the skin is hydrated or sweating. Even more remarkable, direct connections between keratinocytes and neurons, with synapse-like structures, allow instantaneous and direct communication. Electrical transfer resistance is reduced in skin damaged by UV or chemical exposure, as well as in skin conditions such as atopic dermatitis.
Modulating these pathways provides a direct advantage for cosmetic ingredient development. We have developed sophisticated multilayered skin models with variability allowing the inclusion of sebaceous, melanocytic, immune, vascular, and neuronal components, connected to an electrode-based measurement system. Combining these elements with cytokine and neurokinin measurements and electrical stimulation has demonstrated that stimulation of the skin surface with cortisol, menthol, capsaicin, and moisturizers can target cosmetic research faster and more precisely than ever.
Based in Lyon, CTIBiotech is a cutting-edge company specializing in tissue engineering and 3D bioprinting. Its core activity focuses on the design of highly predictive preclinical human tissue models, enabling pharmaceutical and cosmetic industries to test the efficacy of their products with unprecedented accuracy.
Its mission is to accelerate medical innovation while providing an ethical and scientifically relevant alternative to animal testing. By utilizing surgical residues that would otherwise be incinerated, the company transforms these tissue donations into valuable biological resources for research.
Driven by values of scientific excellence, ethics, and respect for life, CTIBiotech strives to transform global research by faithfully reproducing the complexity of human biology to better address the diseases of tomorrow.